Boss Phil Parkinson believes Wrexham can enjoy the "underdog" tag as they begin their 2025-26 Championship campaign at Southampton today (12:30 BST).
Two tiers separated the sides last season, although the Saints are among the promotion favourites this term to secure an immediate return to the Premier League.
Ahead of what will be his side's first season in the second tier since 1981-82, Parkinson says it is difficult to predict what Wrexham can expect against Will Still's outfit.
"There's huge expectation on the teams who have come down and we can enjoy that underdog card going down there," he said.
"What am I expecting? It's difficult to predict their line-up because they've had a few injuries over pre-season and a few players in the background may be moving, they may still be there.
"I'm sure their manager is getting asked the same questions I am.
"If it's three or four weeks into the season, you can predict how teams are going to play and what shape they're going to play, but I think this one is slightly more difficult.
"So it's about concentrating on what we feel we need to do to be at our best at the weekend."
Heading into his fifth campaign as manager with Wrexham, Parkinson has already secured three promotions during his time at the Stok Cae Ras.
And the 57-year-old says he was afforded some time during the off-season to be with his family to reflect on the club's remarkable progress, rising from the National League under the ownership of Hollywood pair Ryan Reynolds and Rob McElhenney.
"There's definitely been some reflection. We all had our separate holidays and it was great to be away with the family and see my parents who live in the North East and spend a bit of time with them to talk about the achievement," he said.
"Once the season is up and running, it's kind of 100mph.
"When you look at the competitiveness of that division (League One), to get promoted was tremendous for us all.
"It was a huge effort. Sometimes people look at us and think 'Wrexham have just spent money, that's it'. No, there's a lot of detail, thought and structure behind the scenes which has taken place to enable us to get those three promotions."